| Clinical Management Clinical management of drug-drug interactions should include prospective and concurrent patient-, disease-and drug-monitoring measures that are sensitive enough to alert the pharmacist or healthcare provider to monitor specific patient-, disease- or drug-therapy parameters and, whenever possible, correlate these findings with clinical laboratory tests. Follow-up monitoring of a patient’s therapy and making appropriate adjustments in the drug regimen can circumvent potentially significant drug interactions. Patients at high risk for drug interactions who also take drugs with a narrow therapeutic index should be monitored more closely for drug interactions, especially when a new drug is added or discontinued. Depending on the drugs in question, likely drug interactions will generally occur within a few days following a change in drug regimen. If two drugs have been identified as having high potential to interact and cause harm, the pharmacist can contact the patient’s physician to obtain an order for another medication that will not cause the troublesome interaction. In some instances a patient’s diet or lack of adherence to a specified diet may be part of the problem. These situations may require the assistance of a dietitian to resolve. |
Clinical Management of Drug
Interactions
Interactions
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