| Digoxin Pharmacodynamic interactions These interactions include those attributed to additive effects and those that involve effects on potassium levels. For example, the concurrent use of digoxin with beta-blockers or calcium channel blockers that have both negative inotropic and chronotropic activity (ie, verapamil or diltiazem), may lead to additive slowing of the heart rate. Concurrent use is considered necessary in some patients when atrial fibrillation cannot be controlled on digoxin alone; however, patients should be monitored for bradycardia, especially on initiation of combination therapy. Patients taking digoxin should also be treated cautiously with drugs that may cause potassium loss such as (Acetazoamide Amphotericn, Beta2 agonis, Crticosteroids, Thiazid, Intracnazole and theophylline). This is because hypokalaemia increases the risk of digoxin toxicity by sensitising the myocardium to the action of digoxin. |
Drug Interactions
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